來自韓國 Ballvic,專為脫髮及頭皮敏感人士而設的醫學品牌,專門研究亞洲人頭髮、頭皮護理,多年豐富的臨床經驗,證實有效的育髮產品,解決脫髮問題及強化毛囊,使頭髮更健康、濃密,激活生髮。
主要成分:
* 藍銅胜肽 (Copper Tripeptide-1): 三胺基酸肽 (L-丙氨酰-L-組氨酰-L-賴氨酸, L-alanyl-L-histidyl-L-lysine) 與銅化合物, 能刺激真皮纖維母細胞增殖並提高血管內皮生長因子(vascular endothelial growth factor) 的產生真皮毛囊乳頭細胞 (Dermal follicle papilla cells) 的增殖,減少轉化生長因子-β1 (TGFβ1) 的分泌。
基礎參考文獻: Pyo, H. K., Yoo, H. G., Won, C. H., Lee, S. H., Kang, Y. J., Eun, H. C., ... & Kim, K. H. (2007). The effect of tripeptide-copper complex on human hair growth in vitro. Archives of pharmacal research, 30, 834-839.
* AP23 (Acid Paste 23): 含有肉荳蔻酸 (myristic acid,透過抑制5α-還原酶 (5α-reductase) 降低毛囊中的DHT (二氫睪酮) 水平。
基礎參考文獻: Mccoy, J. O. H. N., & Ziering, C. R. A. I. G. (2012). Botanical Extracts for the Tr; eatment of Androgenetic Alopecia. International Journal of Life science and Pharma Research, 2(4), 31-38.
* 人蔘提取物: 防止真皮毛囊乳頭細胞 (Dermal follicle papilla cells) 凋亡 (apoptosis) 。抗雄性激素:DHT(二氫睪酮)、5-aR(5α-還原酶)。細胞凋亡抑制:TGF-β(轉化生長因子β)、Smads。增殖活化:WNT、Shh、Gli、VEGF、EGF、AKT/PKB)、ERK 等細胞訊息傳遞路徑。
基礎參考文獻: Choi, B. Y. (2018). Hair-growth potential of ginseng and its major metabolites: a review on its molecular mechanisms. International journal of molecular sciences, 19(9), 2703.
* 綠茶提取物: 含有 EGCG (Epigallocatechin-3-gallate), 抑制5α-還原酶(5α-reductase) 降低毛囊中的DHT (二氫睪酮) 水平。透過上調 Erk 和 Akt 細胞訊息傳遞以及增加 Bcl-2/Bax 比率來刺激真皮毛囊乳頭細胞 (Dermal follicle papilla cells) 生長。
基礎參考文獻: Hiipakka, R. A., Zhang, H. Z., Dai, W., Dai, Q., & Liao, S. (2002). Structure–activity relationships for inhibition of human 5α-reductases by polyphenols. Biochemical pharmacology, 63(6), 1165-1176.
Kwon, O. S., Han, J. H., Yoo, H. G., Chung, J. H., Cho, K. H., Eun, H. C., & Kim, K. H. (2007). Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine, 14(7-8), 551-555.
* 咖啡因: 增強毛幹伸長、延長毛髮生長時間並刺激毛髮基質角質細胞 (hair matrix keratinocyte) 增生。刺激毛囊細胞增殖,抑制細胞凋亡/壞死,上調 IGF-1 基因表現和蛋白質分泌,同時下調 TGF-β2 蛋白質分泌。
基礎參考文獻: Fischer, T. W., Herczeg‐Lisztes, E., Funk, W., Zillikens, D., Bíró, T., & Paus, R. (2014). Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles in vitro. British Journal of Dermatology, 171(5), 1031-1043.